A Review of Teicoplanin Used in the Prevention and Treatment of Serious Infections Caused by Gram-Positive Bacteria and Compared Its Effects with Some other Antibiotics

Teicoplanin is an antibiotic used in the prevention and treatment of serious infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecalis. It is a semi-synthetic glycopeptide antibiotic with a spectrum of activities similar to vancomycin. Its mechanism of action is inhibition of bacterial cell wall synthesis teicoplanin is marketed by Sanofi Aventis Coperation under the brand name of Targocid. It has been shown that oral administration of teicoplanin is effective in the treatment of Pseudomembranous colitis and Clostridium difficile-associated diarrhoea, with comparable efficacy to vancomycin.The effectiveness of this antibiotic is associated with its carbon chain length.It’s tried in this review article to introduce teicoplanin synthases, structure and its structure effect on treatment and also introduce the advantages of teicoplanin in bacterial infection treatment and compared its effects with some other antibiotics like vancomycin and linezolid.Based on the above data, it can be concluded that teicoplanin usage, specially intervenes injection of it, is a successful antibiotic treatment against bacterial infections caused by Gram-positive bacteria, particularly methicillinresistant Staphylococcus aurous (MRSA). The teicoplanin effect is directly related to the length of its carbon chain. It was shown that treatment with combination of teicoplanin and vancomycin or teicoplanin and linezolid have more influence over the treatment process. The most important advantage of teicoplanin usage in treatments is its lower side effects on patients than other antibiotics. Key word:Carbon chain, Gram-positive, Methicillin-resistant Staphylococcus aureus (MRSA), Teicoplanin.